abstract：OBJECTIVE:To review the clinical features, treatment, and outcome of children in the UK with Down's syndrome and acute myeloid leukaemia (AML). DESIGN:A retrospective study of 59 children with Down's syndrome and AML presenting between 1987 and 1995. Data were obtained from hospital case notes, trial records, and by q...

journal_title：Archives of disease in childhood

authors： Craze JL,Harrison G,Wheatley K,Hann IM,Chessells JM

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:To compare dual therapy (omeprazole and amoxicillin) with triple therapy (omeprazole, amoxicillin, and clarithromycin) in the treatment of Helicobacter pylori infection. The efficacy of 1 mg/kg/day omeprazole was randomly compared with 2 mg/kg/day. STUDY DESIGN:252 patients (median age, 11.0 years; range, 3-...

journal_title：Archives of disease in childhood

authors： Behrens R,Lang T,Keller KM,Bindl L,Becker M,Rodeck B,Küster P,Wündisch GF,Stolte M

更新日期：1999-07-01 00:00:00

abstract：:Standing height, sitting height, armspan, subischial leg length, head circumference, and growth hormone-insulin-like growth factor I (IGF-I) axis were determined in 86 patients with osteogenesis imperfecta. The aim of this study was to determine standing height and body proportions and their variability among osteogen...

journal_title：Archives of disease in childhood

authors： Lund AM,Müller J,Skovby F

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Growth hormone insufficiency (GHI) is diagnosed conventionally by short stature and slow growth, and is confirmed by diminished peak GH response to a provocation test. Insulin-like growth factor I (IGF-I) and IGF binding protein 3 (IGFBP-3) have previously been considered individually OBJECTIVE:To test the ...

journal_title：Archives of disease in childhood

authors： Mitchell H,Dattani MT,Nanduri V,Hindmarsh PC,Preece MA,Brook CG

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:To determine the sensitivity of differential avian and human delayed-type hypersensitivity skin testing in the diagnosis of non-tuberculous mycobacterial lymphadenitis. METHOD:Retrospective review of all patients with culture proved non-tuberculous mycobacterial lymph node infections who also had differentia...

journal_title：Archives of disease in childhood

authors： Daley AJ,Isaacs D

更新日期：1999-04-01 00:00:00

abstract：:Fifteen per cent of children treated with growth hormone (GH) are receiving treatment for Turner syndrome, but few results are available on final height in the UK. In this study, data were obtained from the UK KIGS database for 485 girls with Turner syndrome who were treated from 1986, allowing an audit of practice an...

journal_title：Archives of disease in childhood

authors： Betts PR,Butler GE,Donaldson MD,Dunger DB,Johnston DI,Kelnar CJ,Kirk J,Price DA,Wilton P

更新日期：1999-03-01 00:00:00

abstract：:Urinary glycosaminoglycan (GAG) excretion was measured in children with idiopathic urolithiasis (15 girls and 10 boys; mean (SD) age 6.2 (2.4) years) and in healthy controls (10 girls and 14 boys; mean (SD) age 6.8 (3.8) years). GAG excretion was expressed as a GAG/creatinine (mg/g) ratio and was evaluated using dimet...

journal_title：Archives of disease in childhood

authors： Akçay T,Konukoğlu D,Dínçer Y

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:To investigate gastric emptying and intestinal transit of pelleted pancreatin in relation to food boluses. METHODS:Dual isotope scintigraphy combined with breath hydrogen sampling was used to track the concurrent gastric emptying and intestinal transit of 111indium labelled microspheres and a 99mtechnetium l...

journal_title：Archives of disease in childhood

authors： Taylor CJ,Hillel PG,Ghosal S,Frier M,Senior S,Tindale WB,Read N

更新日期：1999-02-01 00:00:00

abstract：:A modified nasopharyngeal tube is described that does not add airway dead space and resistance, is well tolerated, highly successful, and allows simultaneous use of oxygen prongs. This potentially reduces the need for surgical intervention to relieve high upper airway obstruction from Pierre-Robin syndrome and other c...

journal_title：Archives of disease in childhood

authors： Masters IB,Chang AB,Harris M,O'Neil MC

更新日期：1999-02-01 00:00:00

abstract：AIMS:To investigate (1) whether colic cries are acoustically distinct from pre-feed "hunger" cries; (2) the role of the acoustic properties of these cries versus their other properties in accounting for parents' concerns about colic. DESIGN:From a community sample, infants were selected who met Wessel colic criteria f...

journal_title：Archives of disease in childhood

authors： St James-Roberts I

更新日期：1999-01-01 00:00:00

abstract：AIM:To evaluate the risk factors for breakthrough varicella in a follow up study of a cohort of 181 healthy children immunised when aged 9-24 months with a reformulated Oka strain varicella vaccine (SmithKline Beecham Biologicals/Oka). DESIGN:The children were randomised in a double blind manner into one of four group...

journal_title：Archives of disease in childhood

authors： Lim YJ,Chew FT,Tan AY,Lee BW

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:To study the influence of deletion/insertion polymorphism in the 16th intron of the angiotensin converting enzyme (ACE) gene on clinical manifestations of Henoch-Schönlein purpura nephritis. STUDY DESIGN:Cross sectional study. ACE gene polymorphism was determined in patients (4-15 years old at onset) with He...

journal_title：Archives of disease in childhood

authors： Yoshioka T,Xu YX,Yoshida H,Shiraga H,Muraki T,Ito K

更新日期：1998-11-01 00:00:00

abstract：:Twenty six children with hypoglycaemia were diagnosed and followed between 1975 and 1995. Diagnosis was confirmed by a high insulin:glucose ratio, and low free fatty acid and 3-hydroxybutyrate on fasting. All patients were treated with diazoxide at a maximum dose of 20 mg/kg/day. Requirement of a higher dose was consi...

journal_title：Archives of disease in childhood

authors： Cresto JC,Abdenur JP,Bergada I,Martino R

更新日期：1998-11-01 00:00:00

abstract：AIM:To test the hypothesis that overall intelligence quotient (IQ) is decreased in patients with Aarskog syndrome. METHODS:21 boys under 17 years of age with a confirmed clinical diagnosis of Aarskog syndrome were assessed using the Griffiths mental development scales and the British ability scales. RESULTS:IQ ranged...

journal_title：Archives of disease in childhood

authors： Logie LJ,Porteous ME

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVES:To investigate the prevalence of infant crying and maternal soothing techniques in relation to ethnic origin and other sociodemographic variables. DESIGN:A questionnaire survey among mothers of 2-3 month old infants registered at six child health clinics in Amsterdam, the Netherlands. SUBJECTS:A questionna...

journal_title：Archives of disease in childhood

authors： van der Wal MF,van den Boom DC,Pauw-Plomp H,de Jonge GA

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:The prevalence of thyroid disease is increased in Down's syndrome. Most available data come from cross sectional studies. AIMS:To study longitudinally thyroid function in patients with Down's syndrome in Uppsala county (85 patients) up to the age of 25 years. METHODS:Observational study based on yearly fol...

journal_title：Archives of disease in childhood

authors： Karlsson B,Gustafsson J,Hedov G,Ivarsson SA,Annerén G

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:To assess height and body mass index standard deviation scores up to 20 years after treatment for acute lymphoblastic leukaemia (ALL). SUBJECTS AND METHODS:Height and body mass index standard deviation scores were measured in 33 patients (14 boys and 19 girls) with childhood ALL at diagnosis, after the end o...

journal_title：Archives of disease in childhood

authors： Birkebaek NH,Clausen N

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Medium chain acyl-CoA dehydrogenase (MCAD) deficiency is a common disorder of fatty acid oxidation in north west Europe. It is very variable in its clinical consequences and is believed to be considerably underdiagnosed. OBJECTIVE:To investigate the diagnosis and outcome of MCAD deficiency in the UK. METHO...

journal_title：Archives of disease in childhood

authors： Pollitt RJ,Leonard JV

更新日期：1998-08-01 00:00:00

abstract：AIMS:To investigate the nature of the unifocal cortical abnormalities on FDG positron emission tomography (PET) in children with an epileptic encephalopathy but no focal abnormality on electroencephalogram or standard magnetic resonance imaging (MRI). METHODS:Repeat FDG PET, surface rendered high resolution MRI, and s...

journal_title：Archives of disease in childhood

authors： Parker AP,Ferrie CD,Keevil S,Newbold M,Cox T,Maisey M,Robinson RO

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:To investigate possible renal toxicity of long-term gentamicin inhalation in patients with cystic fibrosis. METHODS:Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity was measured during routine respiratory clinic visits. Outpatient records were reviewed for data on long-term gentamicin inhalation, and p...

journal_title：Archives of disease in childhood

authors： Ring E,Eber E,Erwa W,Zach MS

更新日期：1998-06-01 00:00:00

abstract：AIM:To investigate the rate and nature of anxiety symptoms and disorders in children, and their relation to social adversities in a cultural sample not previously researched. METHODS:237 children aged 9 to 13 years living in the Gaza Strip were selected randomly from 112 schools. Children completed the revised manifes...

journal_title：Archives of disease in childhood

authors： Thabet AA,Vostanis P

更新日期：1998-05-01 00:00:00

abstract：:Two girls (a 5 year old and a 21 month old) experiencing mononucleosis syndrome with coincidental human herpesvirus (HHV)-7 and Epstein-Barr virus (EBV) infections are described. One patient had primary HHV-7 infection and reactivated EBV infection. The other had primary HHV-7 and EBV infections. These cases indicated...

journal_title：Archives of disease in childhood

authors： Chiu HH,Lee CY,Lee PI,Lin KH,Huang LM

更新日期：1998-05-01 00:00:00

abstract：:Skinfold standards provide a useful indication of subcutaneous fat. To evaluate skinfold thickness of 252 Cambridge infants over the first 2 years of age, SD scores relative to the Tanner standards were calculated, taking account of skewness in the standards. Cambridge SD scores were low, varying according to age from...

journal_title：Archives of disease in childhood

authors： Paul AA,Cole TJ,Ahmed EA,Whitehead RG

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVES:To investigate outcome, management, and prevention in Munchausen syndrome by proxy, non-accidental poisoning, and non-accidental suffocation. DESIGN:Ascertainment through British Paediatric Surveillance Unit and questionnaires to responding paediatricians. SETTING:The UK and Republic of Ireland, September ...

journal_title：Archives of disease in childhood

authors： Davis P,McClure RJ,Rolfe K,Chessman N,Pearson S,Sibert JR,Meadow R

更新日期：1998-03-01 00:00:00

abstract：:The clinical profile, malignant potential, and management of 17 children with juvenile polyposis (more than five juvenile polyps) were evaluated clinically and endoscopically. Colonoscopy and polypectomy were done three weekly until colonic clearance was achieved, and thereafter two yearly. All polyps were subjected t...

journal_title：Archives of disease in childhood

authors： Poddar U,Thapa BR,Vaiphei K,Rao KL,Mitra SK,Singh K

更新日期：1998-03-01 00:00:00

abstract：:Increased emphasis on strict glycaemic control of insulin dependent diabetes mellitus (IDDM) in young patients may be expected to cause increases in rates of significant hypoglycaemia. To evaluate whether this is the case for a large population based sample of IDDM children and adolescents rates of severe (coma, convu...

journal_title：Archives of disease in childhood

authors： Davis EA,Keating B,Byrne GC,Russell M,Jones TW

更新日期：1998-02-01 00:00:00

abstract：:This report highlights the association between tuberous sclerosis and Wolff-Parkinson-White syndrome. Ten patients with concurrent diagnoses of Wolff-Parkinson-White syndrome and tuberous sclerosis were identified. Wolff-Parkinson-White syndrome presented early in life, nine cases being diagnosed in the first year. Ei...

journal_title：Archives of disease in childhood

authors： O'Callaghan FJ,Clarke AC,Joffe H,Keeton B,Martin R,Salmon A,Thomas RD,Osborne JP

更新日期：1998-02-01 00:00:00

abstract：:A survey was carried out in 10 centres in England and Wales to determine the costs of hearing screening in the first year of life. The screens that were studied were targeted neonatal, universal neonatal, and the health visitor distraction test (HVDT) or alternative surveillance. Valid data were available from five ce...

journal_title：Archives of disease in childhood

authors： Stevens JC,Hall DM,Davis A,Davies CM,Dixon S

更新日期：1998-01-01 00:00:00

abstract：:An indirect fluorescent antibody test for Bartonella henselae, B quintana, and B elizabethae was performed in all 18 children who presented to our paediatric outpatient clinic with cat scratch disease over a six year period. Serum samples were taken on admission, after 15 days, and after six months. Diagnosis was conf...

journal_title：Archives of disease in childhood

authors： Karpathios T,Golphinos C,Psychou P,Garoufi A,Papadimitriou A,Nicolaidou P

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVES:To assess the persistence of serum Haemophilus influenzae type b antibodies and the prevalence of H influenzae type b carriage in a group of preschool age children previously vaccinated in infancy. DESIGN:Names were randomly selected from immunisation records. Families were visited on five occasions over a ...

journal_title：Archives of disease in childhood

authors： Heath PT,Bowen-Morris J,Griffiths D,Griffiths H,Crook DW,Moxon ER

更新日期：1997-12-01 00:00:00

abstract：:A 12 year old Asian girl with a four year history of poorly controlled insulin dependent diabetes mellitus developed overt diabetic nephropathy. There were no clinical features of Rabson-Mendenhall syndrome. Screening for microalbuminuria would have identified incipient diabetic nephropathy and highlighted the importa...

journal_title：Archives of disease in childhood

authors： Francis J,Rose SJ,Raafat F,Milford DV

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVES:The amount of adipose tissue influences pubertal development and fertility in girls. A candidate for mediating this is the hormone leptin, derived from adipocytes. This work was carried out to determine whether the leptin concentration in serum is regulated during pubertal development. SUBJECTS AND METHODS:...

journal_title：Archives of disease in childhood

authors： Carlsson B,Ankarberg C,Rosberg S,Norjavaara E,Albertsson-Wikland K,Carlsson LM

更新日期：1997-11-01 00:00:00

abstract：:The case is reported of an infant with hyperammonaemia secondary to severe distal renal tubular acidosis. A clinical association between increased concentrations of ammonia in serum and renal tubular acidosis has not previously been described. In response to acidosis the infant's kidneys presumably increased ammonia s...

journal_title：Archives of disease in childhood

authors： Miller SG,Schwartz GJ

更新日期：1997-11-01 00:00:00

abstract：:The reliability and validity of the North American paediatric appropriateness evaluation protocol (PAEP) for use in paediatric practice in Britain was tested. The protocol was applied to 418 case records of consecutive emergency admissions to three Yorkshire district general hospitals. The PAEP ratings were then compa...

journal_title：Archives of disease in childhood

authors： Werneke U,Smith H,Smith IJ,Taylor J,MacFaul R

更新日期：1997-10-01 00:00:00

abstract：:The practice of general paediatricians in the initial evaluation of congenital hypothyroidism (CHT) was assessed. This was performed by a questionnaire survey of paediatricians in East Anglia of whom 84% responded. Nineteen of 25 clinicians based in seven district hospitals managed children with CHT. The median number...

journal_title：Archives of disease in childhood

authors： Ahmed SF,Barnes ND,Hughes IA

更新日期：1997-10-01 00:00:00

abstract：:Hepatitis GB virus-C (HGBV-C)/hepatitis G virus (HGV) infection was investigated in 106 children with liver disease (54 boys and 52 girls, mean age 7.3 years); 12 with chronic hepatitis C virus infection, 29 with positive hepatitis B surface antigen, nine with idiopathic fulminant hepatic failure, seven with graft dys...

journal_title：Archives of disease in childhood

authors： Nagata I,Tzampouras N,Chokshi S,Naoumov NV,Cheeseman P,Smith HM,Baker AJ,Williams R,Mieli-Vergani G

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Controlling lung inflammation may be the key to improving morbidity and mortality in cystic fibrosis. OBJECTIVE:To assess the effects of inhaled corticosteroids on lung inflammation in cystic fibrosis. DESIGN:Double blind placebo controlled randomised sequence crossover trial. Fluticasone propionate (400 m...

journal_title：Archives of disease in childhood

authors： Balfour-Lynn IM,Klein NJ,Dinwiddie R

更新日期：1997-08-01 00:00:00

abstract：:Primary human herpesvirus 6 (HHV-6) and 7 (HHV-7) infections were identified in febrile children by qualitative and quantitative polymerase chain reaction (PCR) assays. Diagnosis was based on the differential detection of viral DNA in peripheral blood mononuclear cells (PBMC), but not in saliva. Six of 41 febrile infa...

journal_title：Archives of disease in childhood

authors： Clark DA,Kidd IM,Collingham KE,Tarlow M,Ayeni T,Riordan A,Griffiths PD,Emery VC,Pillay D

更新日期：1997-07-01 00:00:00

abstract：:Atypical, non-diarrhoea associated haemolytic uraemic syndrome (D-HUS) is a heterogeneous disorder with a generally poor outcome, although this view has now been questioned. The clinical and laboratory features of 23 children with D-HUS, representing a third of all patients with HUS seen during the last 26 years, were...

journal_title：Archives of disease in childhood

authors： Neuhaus TJ,Calonder S,Leumann EP

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:To determine whether antimony may be detected in the urine during infancy and early childhood and its association with passive exposure to tobacco smoke, as assessed by urinary cotinine. DESIGN:Analysis of spare aliquots of urine collected from infants participating in studies of respiratory function and pas...

journal_title：Archives of disease in childhood

authors： Dezateux C,Delves HT,Stocks J,Wade A,Pilgrim L,Costeloe K

更新日期：1997-05-01 00:00:00